| Autor: |
Oonchit Suparerk, Cherdhirunkorn Benya, Tharabenjasin Phuntila, Pabalan Noel, Chintanavilas Kumpol, Marks Robert, Parcharoen Yardnapar, Pechyen Chiravoot |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
The EuroBiotech Journal, Vol 7, Iss 3, Pp 144-154 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2564-615X |
| DOI: |
10.2478/ebtj-2023-0010 |
| Popis: |
This study aimed to modify screen-printed carbon micro-electrode surfaces by coating them with multiwall carbon-based nanotubes conjugated with chitosan and then validated the formed multiwall carbon-based nanotubes-chitosan coated screen printed carbon micro-electrode for the detection of homocysteine, a biomarker analyte known as a risk indicator in cardiovascular disease. The microstructure surface and crystallographic structure stability of the formed multiwall carbon-based nanotubes-chitosan obtained at formed multiwall carbon-based nanotubes per chitosan ratios of 1:1, 2:1, 3:1, and 4:1 were examined via field emission scanning electron microscopy, X-ray radiation, Raman spectroscopy, surface area and pore size, and thermogravimetric analyses. Homocysteine solutions at 30–100 µM were measured by cyclic voltammetry using the different formed multiwall carbon-based nanotubes-chitosan compositions as sensor electrodes. That with an optimal formed multiwall carbon-based nanotubes per chitosan ratio of 4:1 showed the highest crystallinity and electrical conductivity and gave a high coefficient of determination (R2 = 0.9036) between the homocysteine concentration and the oxidation current detection over an operating range of 30–100 µM. This new composite microelectrode for detecting homocysteine concentration makes it a promising candidate for clinical applications. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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