| Autor: |
Amina Aounallah, Ines Lahouel, Lobna Boussofara, Sana Mokni, Najet Ghariani, Mouna Korbi, Wafa Saidi, Badreddine Sriha, Mohamed Denguezli, Colandane Belajouza, Rafiaa Nouira |
| Jazyk: |
English<br />Spanish; Castilian<br />French<br />Polish |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nasza Dermatologia Online, Vol 8, Iss 3, Pp 255-259 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2081-9390 |
| DOI: |
10.7241/ourd.20173.74 |
| Popis: |
Introduction: Pemphigoid gestationis (PG) is a rare autoimmune bullous dermatosis occurring during pregnancy and post partum. The aim of our study was to analyse epidemio-clinical, immunopathological, therapeutic and prognostic features of PG through a hospital study of 44 cases. Methods: It is a retrospective study, collecting all cases diagnosed at the dermatological department of Farhat Hached Soussa (Tunisia) from January 1990 to December 2015. Results: The disease began in 40,9% of cases at the second trimester of pregnancy and 48% at the third trimester of pregnancy, one case in post abortum. It was a polymorphic eruption, localized in the chest, the back and limbs in all cases. The face was affected in 18,2% of cases and the mucosa in one case. The skin biopsy showed a subepidermal blister in 25 cases. The direct immunofluoresence found linear C3 deposits along the basement membrane in all cases, associated to IgG deposits in 25% of cases. The treatment was mainly based on local or general corticotherapy with favourable evolution. We noted exacerbation in post partum in 17 cases and relapses during the ulterior pregnancies in 7 cases. Fetal damage was present in PG in 8 cases. Conclusion: Our study is conformed to literature data; nevertheless, it is distinguished by its appearance on the face the less frequency of palmo-plantar manifestations and the exceptional case of PG postabortum. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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