Myasthenia Gravis Revealing Hodgkin’s Lymphoma

Autor: Jaouad Yousfi, Fatimazahra Bensalek, Mouna Zahlane, Laila Benjilali, Lamiaa Essaadouni
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: European Journal of Case Reports in Internal Medicine (2021)
Druh dokumentu: article
ISSN: 2284-2594
DOI: 10.12890/2021_2375
Popis: Introduction: Myasthenia gravis is a rare autoimmune disease caused by autoantibodies directed against the synapses of the neuromuscular junction. Patient and methods: We report the case of a young patient with myasthenia gravis associated with Hodgkin's lymphoma. Results: A 22-year-old patient presented with a 2-month history of severe weakness associated with muscle fatigability and intermittent ptosis without dysphonia or respiratory signs. Clinical examination revealed generalized myasthenia. The EMG did not show post-synaptic block, and anti-acetylcholine receptor antibodies were elevated at 3 nmol/l (normal ?0.3 nmol/l). CT of the thorax showed an anterior medial mass. Immunohistochemistry of the mass revealed mixed cellularity Hodgkin’s lymphoma. Conclusion: The association of lymphomas with myasthenia gravis has been rarely reported.
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