F4-neuroprostanes and F2-dihomo-isoprostanes: biomarkers and bioactive oxylipins

Autor:	Durand Thierry, Bultel-Poncé Valérie, Guy Alexandre, Gros Valérie, Reversat Guillaume, Vigor Claire, Galano Jean-Marie, Oger Camille
Jazyk:	English<br />French
Rok vydání:	2023
Předmět:	biomarkers docosahexaenoic acid radical peroxidation neuroprostanes dihomo-isoprostanes bioactive oxylipins total synthesis Oils fats and waxes TP670-699
Zdroj:	Oilseeds and fats, crops and lipids, Vol 30, p 10 (2023)
Druh dokumentu:	article
ISSN:	2272-6977 2257-6614
DOI:	10.1051/ocl/2023008
Popis:	Under condition of oxidative stress, free radical-catalyzed peroxidation of docosahexaenoic acid (DHA) and adrenic acid (AdA) generates in vivo neuroprostanes (NeuroPs) and dihomo-isoprostanes (dihomo-IsoPs), among a large number of key products participating in many pathophysiological processes. These non-enzymatic oxygenated metabolites display a wide range of biological actions (especially DHA-metabolites), and some of them are now considered as the most reliable indicators of oxidative stress in neurogenerative, neurodevelopmental or cardiovascular diseases. In this review, we will present an overview regarding neuroprostanes and dihomo-isoprostanes and discuss about their biological interests.
Databáze:	Directory of Open Access Journals
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