| Autor: |
Tommas J. Ellender, Sophie V. Avery, Kashif Mahfooz, Jakub Scaber, Alexander von Klemperer, Sophie L. Nixon, Matthew J. Buchan, Joram J. van Rheede, Aleksandra Gatti, Cameron Waites, Hania J. Pavlou, David Sims, Sarah E. Newey, Colin J. Akerman |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-13206-1 |
| Popis: |
Glutamatergic neurons in the mammalian cortex are born from a heterogeneous pool of embryonic progenitors, however, it is unclear how these different progenitors contribute to diversity within the mature cortex. In this study, authors combine in utero progenitor labeling techniques with targeted Patch-Seq methods and high resolution synaptic circuit mapping in the mature mouse cortex to show that intermediate progenitors can generate restricted sets of transcriptomically-defined glutamatergic neurons that have distinct patterns of local and long-range synaptic connections. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
