Does Normalised Apparent Diffusion Coefficient Further Improve the Diagnostic Accuracy of Diffusion-Weighted MRI at 3T in Characterising Breast Masses?
| Autor: | Varsha S Hardas, Aparna H Chandorkar, Aparna A Atre |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 13, Iss 4, Pp TC01-TC06 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2019/40523.12800 |
| Popis: | Introduction: In recent times, a significant rise has been observed in the incidence of breast cancer among Indian women. Breast Magnetic Resonance Imaging (MRI) plays an adjuvant role in the high risk screening, diagnosis, staging and follow-up of breast cancer. It is used as a complementary tool to mammography and ultrasound for the diagnostic work-up of breast masses. An advanced MRI technique such as DiffusionWeighted Imaging (DWI) with quantitative absolute and normalised Apparent Diffusion Coefficient (ADC) measurements is employed to improve the diagnostic performance of ContrastEnhanced Breast MRI (CE-MRI). Aim: To assess whether glandular tissue-normalised Apparent Diffusion Coefficient (nADC) could further improve the diagnostic accuracy of MRI, in characterising benign versus malignant breast masses. Materials and Methods: This cross-sectional study included 39 patients with 51 focal breast masses. These patients underwent CE-MRI and DWI, on a 3T MR system. Absolute ADC values and glandular tissue-normalised ADC values were measured in the breast masses satisfying the inclusion criteria. The diagnostic accuracy and kappa measure of agreement between the diagnoses obtained from various imaging techniques (independently and in combination) and the final histopathology/ follow-up results were calculated. Results: Twenty six (51%) of the 51 breast masses were benign and 25 (49%) were malignant. The mean nADC value (0.619+0.21×10−3 mm2 /sec) obtained from malignant breast masses was significantly lower than the mean nADC value (0.98+0.26×10−3 mm2 /sec) measured from benign breast masses (p |
| Databáze: | Directory of Open Access Journals |
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