Toxicity Assessment of SiO2 and TiO2 in Normal Colon Cells, In Vivo and in Human Colon Organoids

Autor:	Sung Bum Park, Won Hoon Jung, Ki Young Kim, Byumseok Koh
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	silicon dioxide nanoparticle titanium dioxide nanoparticle cytotoxicity in vivo toxicity colon organoids Organic chemistry QD241-441
Zdroj:	Molecules, Vol 25, Iss 16, p 3594 (2020)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules25163594
Popis:	We conducted systemic assessments on the toxicity of silicon dioxide (SiO2) and titanium dioxide (TiO2) nanoparticles using different forms of normal colon cells (CCD-18Co), in vivo and in human colon organoids. The in vivo acute oral toxicity data showed that the LD50 values are greater than 2000 mg/kg for both the SiO2 and TiO2 nanoparticles; however, the SiO2 and TiO2 nanoparticles induced cytotoxicity in two-dimensional CCD-18Co cells and three-dimensional CCD-18Co spheroids and human colon organoids, with IC50 values of 0.6, 0.8 and 0.3 mM for SiO2 and 2.5, 1.1 and 12.5 mM for TiO2 nanoparticles, respectively. The data suggest that, when SiO2 and TiO2 are in nanoparticle form, cytotoxicity is induced; thus, care should be taken with these materials.
Databáze:	Directory of Open Access Journals
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