| Autor: |
Kazutaka Terahara, Takashi Sato, Yu Adachi, Keisuke Tonouchi, Taishi Onodera, Saya Moriyama, Lin Sun, Tomohiro Takano, Ayae Nishiyama, Ai Kawana-Tachikawa, Tetsuro Matano, Takayuki Matsumura, Masaharu Shinkai, Masanori Isogawa, Yoshimasa Takahashi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
iScience, Vol 25, Iss 9, Pp 104959- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2589-0042 |
| DOI: |
10.1016/j.isci.2022.104959 |
| Popis: |
Summary: Determinants of memory T cell longevity following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain unknown. In addition, phenotypes associated with memory T cell longevity, antibody titers, and disease severity are incompletely understood. Here, we longitudinally analyzed SARS-CoV-2-specific T cell and antibody responses of a unique cohort with similar numbers of mild, moderate, and severe coronavirus disease 2019 cases. The half-lives of CD4+ and CD8+ T cells were longer than those of antibody titers and showed no clear correlation with disease severity. When CD4+ T cells were divided into Th1-, Th2-, Th17-, and Tfh-like subsets, the Th17-like subset showed a longer half-life than other subsets, indicating that Th17-like cells are most closely correlated with T cell longevity. In contrast, Th2- and Tfh-like T cells were more closely correlated with antibody titers than other subsets. These results suggest that distinct CD4+ T cell subsets are associated with longevity and antibody responses. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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