EXPRESSION OF NEGATIVE TRANSCRIPTION REGULATORS IN PERIPHERAL BLOOD MONONUCLEARS IN PATIENTS WITH BRONCHIAL ASTHMA

Autor:	V. V. Lim, V. A. Ivanov, L. N. Sorokina, V. N. Mineev, M. A. Nyoma, V. I. Trofimov
Jazyk:	ruština
Rok vydání:	2016
Předmět:	bronchial asthma socs-proteins socs3 socs5 mononuclear blood cells Immunologic diseases. Allergy RC581-607
Zdroj:	Медицинская иммунология, Vol 18, Iss 5, Pp 451-458 (2016)
Druh dokumentu:	article
ISSN:	1563-0625 2313-741X
DOI:	10.15789/1563-0625-2016-5-451-458
Popis:	Sixty patients with allergic bronchial asthma (ABA) and forty-one, with non-allergic bronchial asthma (NABA), as well as 23 healthy controls were under study. Expression of the SOCS5 mRNA from mononuclear blood cells was analyzed by RT-PCR. In patients with bronchial asthma, (ABA and NABA) we determined a significant increase of mRNA expression levels for a SOCS5 negative transcription regulator in peripheral blood mononuclears, in comparison with control group. Thus, an increase of SOCS5-expression, and of the SOCS3 mRNA expression in patients with BA may be associated with protective anti-inflammatory response.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b2e0609efee8404b914df3d33d24c443 Zobrazit plný text záznamu View record in DOAJ