Associations between immune cell phenotypes and lung cancer subtypes: insights from mendelian randomization analysis

Autor: Jin-Min Zheng, Chen-Xi Lou, Yu-Liang Huang, Wen-Tao Song, Yi-Chen Luo, Guan-Yong Mo, Lin-Yuan Tan, Shang-Wei Chen, Bai-Jun Li
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Pulmonary Medicine, Vol 24, Iss 1, Pp 1-12 (2024)
Druh dokumentu: article
ISSN: 1471-2466
DOI: 10.1186/s12890-024-03059-w
Popis: Abstract Introduction Lung cancer is a common malignant tumor, and different types of immune cells may have different effects on the occurrence and development of lung cancer subtypes, including lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). However, the causal relationship between immune phenotype and lung cancer is still unclear. Methods This study utilized a comprehensive dataset containing 731 immune phenotypes from the European Bioinformatics Institute (EBI) to evaluate the potential causal relationship between immune phenotypes and LUSC and LUAD using the inverse variance weighted (IVW) method in Mendelian randomization (MR). Sensitivity analyses, including MR-Egger intercept, Cochran Q test, and others, were conducted for the robustness of the results. The study results were further validated through meta-analysis using data from the Transdisciplinary Research Into Cancer of the Lung (TRICL) data. Additionally, confounding factors were excluded to ensure the robustness of the findings. Results Among the final selection of 729 immune cell phenotypes, three immune phenotypes exhibited statistically significant effects with LUSC. CD28 expression on resting CD4 regulatory T cells (OR 1.0980, 95% CI: 1.0627–1.1344, p
Databáze: Directory of Open Access Journals
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