| Autor: |
Huan LI, Xiaole LIU, Mengxi WANG, Yaxing YANG, Qing SHANG, Yongli SHI |
| Jazyk: |
čínština |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of Hebei University of Science and Technology, Vol 40, Iss 3, Pp 215-225 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1008-1542 |
| DOI: |
10.7535/hbkd.2019yx03004 |
| Popis: |
In order to compare the properties of polyethylene glycol-polycaprolactone（PEG-PCL）with different structures, the PCL-PEG-PCL and mPEG-b-PCL copolymers are obtained by ring-opening polymerization method and characterized by FT-IR, 1H-NMR and GPC. The curcumin-loaded nanoparticles of "mushroom" and "brush" are prepared via self-assembly method, and the properties of the two structural nanoparticles are studied. The results show that CUR is encapsulated into the nanoparticles with an amorphous state; the nanoparticles show a smooth surface with core-shell structures and good dispersibility. Influenced by the structure of the copolymer, the "mushroom" nanoparticles have a smaller average particle size of (105.71±3.20)nm, a higher drug loading and encapsulation efficiency. Since the surface of the PCL-PEG-PCL nanoparticles forms a dense PEG-layer, protein resistance studies show that the "mushroom" nanoparticles are good in vivo stability. "Brush" nanoparticles have a lower CMC date and better sustained release properties, and have a higher inhibitory effect on HepG-2 cancer cell proliferation. The study of drug-loaded nanoparticles can provide reference for drug delivery system selection and clinical application of nanoparticles with different structures. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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