Adverse effects of BMPR2 suppression in macrophages in animal models of pulmonary hypertension
| Autor: | James West, Xinping Chen, Ling Yan, Santhi Gladson, James Loyd, Hamid Rizwan, Megha Talati |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Pulmonary Circulation, Vol 10 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2045-8940 20458940 |
| DOI: | 10.1177/2045894019856483 |
| Popis: | Inflammatory cells contribute to irreversible damage in pulmonary arterial hypertension (PAH). We hypothesized that in PAH, dysfunctional BMPR2 signaling in macrophages contributes to pulmonary vascular injury and phenotypic changes via proinflammatory cytokine production. Studies were conducted in: (1) Rosa26-rtTA2 3 X TetO7-Bmpr2delx4 FVB/N mice (mutant Bmpr2 is universally expressed, BMPR2 delx4 mice) given a weekly intra-tracheal liposomal clodronate injections for four weeks; and (2) LysM-Cre X floxed BMPR2 X floxed eGFP monocyte lineage-specific BMPR2 knockout (KO) mouse model (Bmpr2 gene expression knockdown in monocytic lineage cells) (BMPR2 KO ) following three weeks of sugen/hypoxia treatment. In the BMPR2 delx4 mice, increased right ventricular systolic pressure (RVSP; P |
| Databáze: | Directory of Open Access Journals |
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