| Autor: |
Jesús Valencia-Cervantes, Martha Patricia Sierra-Vargas |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Analytical Cellular Pathology, Vol 2024 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2210-7185 |
| DOI: |
10.1155/2024/5523283 |
| Popis: |
Solid tumors frequently experience hypoxia or low O2 levels. In these conditions, hypoxia-inducible factor 1 alpha (HIF-1α) is activated and acts as a transcription factor that regulates cancer cell adaptation to O2 and nutrient deprivation. HIF-1α controls gene expression associated with various signaling pathways that promote cancer cell proliferation and survival. MicroRNAs (miRNAs) are 22-nucleotide noncoding RNAs that play a role in various biological processes essential for cancer progression. This review presents an overview of how hypoxia regulates the expression of multiple miRNAs in the progression of cancer cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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