| Autor: |
Valentina Magri, Simone Scagnoli, Gabriele Piesco, Giulia Pomati |
| Jazyk: |
English<br />Italian |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
AboutOpen, Vol 4, Iss 1 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2465-2628 |
| DOI: |
10.19156/abtpn.2018.0071 |
| Popis: |
We report the case of a young, 36-year-old patient diagnosed with multifocal breast carcinoma, undergoing neoadjuvant chemotherapy, surgery and adjuvant treatment. The patient presented an early recovery of liver disease after only 7 months of free interval. Histological reevaluation after liver biopsy revealed a HER2-positive disease, for which it was treated with first line chemotherapy including double anti-HER2 block. After 3 cycles the disease progressed at liver and encephalic level. It was therefore decided to treat brain localizations with whole-brain radiotherapy and to start a second line with capecitabine associated with lapatinib. This chemo-radiotherapy approach allowed to control the disease for 8 months. Following further progression (lymph node and bone), a third line was chosen with trastuzumab emtansine (TDM1). The encephalic disease remained stable for another 8 months, when due to visceral progression and worsening of clinical picture, TDM1 was interrupted and supportive therapies were started (Oncology). . |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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