Effects of angiotensin receptor-neprilysin inhibitor on ketone body metabolism in pre-heart failure/heart failure patients

Autor:	Yusuke Kashiwagi, Tomohisa Nagoshi, Yoshiro Tanaka, Yuhei Oi, Haruka Kimura, Kazuo Ogawa, Makoto Kawai, Michihiro Yoshimura
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Angiotensin receptor-neprilysin inhibitor (ARNI) Ketone body Heart failure Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-67524-6
Popis:	Abstract Recently, a mild elevation of the blood ketone levels was found to exert multifaceted cardioprotective effects. To investigate the effect of angiotensin receptor neprilysin inhibitors (ARNIs) on the blood ketone body levels, 46 stable pre-heart failure (HF)/HF patients were studied, including 23 who switched from angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) to ARNIs (ARNI group) and 23 who continued treatment with ACE inhibitors or ARBs (control group). At baseline, there were no significant differences in the total ketone body (TKB) levels between the two groups. Three months later, the TKB levels in the ARNI group were higher than the baseline values (baseline to 3 months: 71 [51, 122] to 92 [61, 270] μmol/L, P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b2bbff4bd3ce4c998d14da9b67a501a2 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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