The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study

Autor: Aksam Yassin, Farid Saad, Mustafa Alwani, Omar M. Aboumarzouk, Raed M. Al-Zoubi, Joanne Nettleship, Daniel Kelly, Abdulla Al-Ansari
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The Aging Male, Vol 25, Iss 1, Pp 185-191 (2022)
Druh dokumentu: article
ISSN: 13685538
1473-0790
1368-5538
DOI: 10.1080/13685538.2022.2099828
Popis: Testosterone therapy (TTh) is the primary treatment for aging men with functional hypogonadism. Whilst the benefits of testosterone (T) replacement are well-evidenced, the long-term data for TTh on metabolic and endocrine parameters is limited. Here we present the effect of TTh on endocrine parameters in hypogonadal men at a 12-year follow-up. In this single-centre, cumulative, prospective, registry study, 321 hypogonadal men (mean age: 58.9 years) received testosterone undecanoate injections in 12-week intervals for up to 12 years. Blood samples were taken at every other visit to measure levels of total T (TT), calculated free T, sex hormone-binding globulin (SHBG), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone and prolactin. We observed an increase in TT of 15.5 nmol/L (p
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