Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity
| Autor: | Mahmood A. Hamed, Seiichi Nakata, Kazuya Shiogama, Kenji Suzuki, Ramadan H. Sayed, Yoichi Nishimura, Noboru Iwata, Kouhei Sakurai, Badawy S. Badawy, Ken-ichi Inada, Hayato Tsuge, Yutaka Tsutsumi |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Clinical and Experimental Otorhinolaryngology, Vol 10, Iss 3, Pp 213-220 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1976-8710 2005-0720 |
| DOI: | 10.21053/ceo.2016.01263 |
| Popis: | Objectives Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity. Continued research is necessary to clarify factors related to its aggressiveness. We aimed to investigate the expression of Ki-67, cytokeratin 13 (CK13) and cytokeratin 17 (CK17) in acquired nonrecurrent human cholesteatoma and correlate them with its bone destructive capacity. Methods A prospective quantitative immunohistochemical study was carried out using fresh acquired cholesteatoma tissues (n=19), collected during cholesteatoma surgery. Deep meatal skin tissues from the same patients were used as control (n=8). Cholesteatoma patients were divided into 2 groups and compared (invasive and noninvasive) according to a grading score for bone resorption based upon clinical, radiologic and intraoperative findings. To our knowledge, the role of CK17 in cholesteatoma aggressiveness was first investigated in this paper. Results Both Ki-67 and CK17 were significantly overexpressed in cholesteatoma than control tissues (P |
| Databáze: | Directory of Open Access Journals |
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