Protective and antioxidant effects of silymarin in sheep with fasciolosis treated by clorsulon
| Autor: | Mehrzad Aflatooni, negar panahi, Pejman Mortazavi, Bahar Shemshadi, Shapoor Kakoolaki |
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| Jazyk: | perština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, Vol 15, Iss 2 (58) تابستان, Pp 169-186 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2322-4746 2476-6984 |
| DOI: | 10.30495/jvcp.2021.1918402.1288 |
| Popis: | Fasciolosis is a parasitic disease that causes economic losses. In the present study, the protective effects of silymarin alone and in combination with clorsulon were investigated in sheep naturally infected with Fasciola hepatica. For this purpose, 40 Sangsari breed sheep were used, which were divided into five groups, including 1- healthy sheep without treatment 2- fasciolosis affected sheep without treatment 3- fasciolosis affected sheep treated with silymarin 4- fasciolosis affected sheep treated with Clorsulon, and 5- fasciolosis affected sheep treated with silymarin and clorsulon. Biochemical parameters including triglyceride, total bilirubin, total protein, cholesterol, and albumin, were measured. The serum level of malondialdehyde, total antioxidant capacity, and hematological parameters were determined and compared among groups. Additionally, histopathological changes were investigated using light microscopy. Biochemical analysis showed significant improvement in bilirubin levels, total protein, cholesterol, and albumin in sheep treated with silymarin and clorsulon (p |
| Databáze: | Directory of Open Access Journals |
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