Molecular heterogeneity and treatment outcome of EGFR exon 20 insertion mutations in Chinese patients with advanced non-small cell lung cancer: insights from a large-scale real-world study

Autor:	Weirui Wu, Silin Yu, Jinsheng Huang, Qi Qi, Yongyi Wu, Jun Dong
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Non-small cell lung cancer Advanced lung cancer EGFR mutations EGFR exon 20 insertions Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-024-12773-x
Popis:	Abstract Introduction This retrospective study aimed to investigate treatment patterns and outcomes in patients with NSCLC harboring EGFR20ins in China. EGFR20ins mutations are associated with poor responses to EGFR-TKIs, and limited real-world data exist regarding the efficacy of various treatment modalities. Methods In this retrospective, single-center study, treatment outcomes, including PFS and ORR, were evaluated for different treatment regimens based on imaging assessments. The impact of mutation heterogeneity on treatment efficacy was also explored. Results Data from 302 patients diagnosed with NSCLC with EGFR20ins were analyzed. EGFR-TKI monotherapy demonstrated suboptimal PFS compared to platinum-based chemotherapy in the first-line setting (3.00 m vs. 6.83 m, HR = 3.674, 95%CI = 2.48–5.44, p
Databáze:	Directory of Open Access Journals
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