| Autor: |
Pradeep Kumar, Balasubramanian Narasimhan, Kalavathy Ramasamy, Vasudevan Mani, Rakesh Kumar Mishra, Abu Bakar Abdul Majeed |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Arabian Journal of Chemistry, Vol 10, Iss S2, Pp S3740-S3748 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
1878-5352 |
| DOI: |
10.1016/j.arabjc.2014.05.010 |
| Popis: |
In the present study, a series of 2/3-bromo-N′-(substituted benzylidene/3-phenylallylidene)benzohydrazides was synthesized and evaluated in vitro for its antimicrobial and anticancer potentials. The results of antimicrobial and anticancer study indicated that compounds 3, 15 and 18 (pMICam = 1.62 μM/ml) were found to be most potent antimicrobial agents and compound 4 (IC50 = 1.88 ± 0.03 μM) was found to be the most potent anticancer agent. The results of QSAR analysis indicated the importance of topological parameters, Balaban index (J) and valence first and second order molecular connectivity indices (1χv and 2χv) in describing antimicrobial activity of the synthesized benzohydrazides. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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