Patients hospitalized with active tuberculosis and Covid-19 coinfection: A matched case-control from the Brazilian Covid-19 Registry
| Autor: | RAFAEL L.R. CARVALHO, GABRIELLA G. AGUIAR, JESSICA F.B. MOREIRA, DANIELLA N. PEREIRA, VALÉRIA MARIA AUGUSTO, ALEXANDRE V. SCHWARZBOLD, CAROLINA C. MATOS, DANYELLE R.A. RIOS, FELÍCIO R. COSTA, FERNANDO ANSCHAU, JOSÉ MIGUEL CHATKIN, KAREN B. RUSCHEL, MARCELO CARNEIRO, NEIMY R. DE OLIVEIRA, PEDRO G. PARAÍSO, RUBIA LAURA O. AGUIAR, GENNA MAIRA S. GRIZENDE, MILENA S. MARCOLINO |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 96, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1678-2690 0001-3765 91441188 |
| DOI: | 10.1590/0001-3765202420230791 |
| Popis: | Abstract Although control of Covid-19 has improved, the virus continues to cause infections, such as tuberculosis, that is still endemic in many countries, representing a scenario of coinfection. To compare Covid-19 clinical manifestations and outcomes between patients with active tuberculosis infection and matched controls. This is a matched case-control study based on data from the Brazilian Covid-19 Registry, in hospitalized patients aged 18 or over with laboratory confirmed Covid-19 from March 1, 2020, to March 31, 2022. Cases were patients with tuberculosis and controls were Covid-19 patients without tuberculosis. From 13,636 Covid-19, 36 also had active tuberculosis (0.0026%). Pulmonary fibrosis (5.6% vs 0.0%), illicit drug abuse (30.6% vs 3.0%), alcoholism (33.3% vs 11.9%) and smoking (50.0% vs 9.7%) were more common among patients with tuberculosis. They also had a higher frequency of nausea and vomiting (25.0% vs 10.4%). There were no significant differences in in-hospital mortality, mechanical ventilation, need for dialysis and ICU stay. Patients with TB infection presented a higher frequency of pulmonary fibrosis, abuse of illicit drugs, alcoholism, current smoking, symptoms of nausea and vomiting. The outcomes were similar between them. |
| Databáze: | Directory of Open Access Journals |
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