Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactions

Autor: C. T. Watson, A. T. Cohain, R. S. Griffin, Y. Chun, A. Grishin, H. Hacyznska, G. E. Hoffman, N. D. Beckmann, H. Shah, P. Dawson, A. Henning, R. Wood, A. W. Burks, S. M. Jones, D. Y. M. Leung, S. Sicherer, H. A. Sampson, A. J. Sharp, E. E. Schadt, S. Bunyavanich
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-017-02188-7
Popis: Rising rates of peanut allergy pose a public health problem. Here, the authors profile blood transcriptomes during double-blind, placebo-controlled oral challenge in peanut-allergic children to identify gene and cell composition changes, and construct causal networks to detect key allergic reaction drivers.
Databáze: Directory of Open Access Journals