Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice

Autor:	Zhao Wei, Xinlei Zhang, Huifang Nie, Lin Yao, Yanqin Liu, Zhibing Zheng, Qin Ouyang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	organophosphate acetylcholinesterase non-oximes reactivators Mannich phenol Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 3, p 1096 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27031096
Popis:	A family of novel efficient non-oxime compounds exhibited promising reactivation efficacy for VX and sarin inhibited human acetylcholinesterase was discovered. It was found that aromatic groups coupled to Mannich phenols and the introduction of imidazole to the ortho position of phenols would dramatically enhance reactivation efficiency. Moreover, the in vivo experiment was conducted, and the results demonstrated that Mannich phenol L10R1 (30 mg/kg, ip) could afford 100% 48 h survival for mice of 2*LD50 sarin exposure, which is promising for the development of non-oxime reactivators with central efficiency.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/aeb2384e871c48acb939ad2483fa1ada Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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