| Autor: |
Qian Dou, Yatao Lang, Huiying Zeng, Chao-Jun Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Fundamental Research, Vol 1, Iss 6, Pp 742-746 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2667-3258 |
| DOI: |
10.1016/j.fmre.2021.06.018 |
| Popis: |
Transition-metal catalyzed cross-couplings of aryl halides (ArI, ArBr and ArCl) with a broad range of nucleophiles have been developed as powerful methods for carbon–carbon and carbon–heteroatom bonds formation. However, due to the high bond dissociation energy of unactivated C(sp2)–F, cross-couplings of mono-fluoroarenes are the most challenging, especially without using transition-metal catalysts. Herein, a photo-induced transition-metal and external photosensitizer free defluorophosphonation of monofluoroarenes via unactivated C(sp2)–F bond cleavage is reported. Different mono-fluoroarenes have been successfully cross-coupled with dialkyl phosphites in moderate to excellent yields under mild conditions. Mechanistic studies have revealed the possible involvement of a photo-induced SET process and aryl free radical intermediates. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
