| Autor: |
Noriko Motoki, Masaru Mizuki, Teruomi Tsukahara, Momoko Miyakawa, Shutaro Kubo, Hirotsugu Oda, Miyuki Tanaka, Koji Yamauchi, Fumiaki Abe, Tetsuo Nomiyama |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Frontiers in Pediatrics, Vol 8 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2296-2360 |
| DOI: |
10.3389/fped.2020.00233 |
| Popis: |
Objective: We investigated the effects of lactoferrin (LF)-fortified formula on acute gastrointestinal and respiratory symptoms in children.Design: Randomized, double-blind, placebo-controlled trial.Setting and subjects: Children aged 12–32 months in Japan.Intervention: Intake of placebo or LF (48 mg/day)-fortified formula for 13 weeks.Primary endpoint: Prevalence of acute gastrointestinal and respiratory symptom.Results: One hundred nine participants were randomized. Eight participants were lost to follow-up, withdrew consent, or were deemed inappropriate for the trial, with 101 participants receiving complete analyses (placebo group, n = 48; LF group, n = 53).Outcomes: The prevalence of acute gastrointestinal symptoms was significantly less in the LF group (22/53 [41.5%]) than in the placebo group (30/48 [62.5%], p = 0.046). The total number of days having acute respiratory symptoms was significantly lower in the LF group (9.0) than in the placebo group (15.0, p = 0.030).Harms: The rate of adverse events was similar between the groups. No adverse drug reactions were found.Conclusions: LF intake decreased the prevalence of acute gastrointestinal symptoms in children aged 12–32 months. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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