5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients

Autor: Kevin C. Johnson, E. Andres Houseman, Jessica E. King, Katharine M. von Herrmann, Camilo E. Fadul, Brock C. Christensen
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms13177
Popis: Glioblastomas have distorted epigenomes. Here, the authors compare the genome-wide profiles of 5-methylcytosine and 5- hydroxymethylcytosine in glioblastoma and prefrontal cortex tissue reporting a correlation between these profiles and patients’ prognosis.
Databáze: Directory of Open Access Journals