Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population
| Autor: | Gaye Güler Tezel, Ebru Şener, Çisel Aydın, Sevgen Önder |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Balkan Medical Journal, Vol 34, Iss 6, Pp 567-571 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2146-3123 2146-3131 |
| DOI: | 10.4274/balkanmedj.2017.0297 |
| Popis: | Aims: Epidermal growth factor receptor mutation analysis in non-small cell lung cancer is important for selecting patients who will receive treatment with tyrosine kinase inhibitors. In this study, we aimed to investigate the prevalence of epidermal growth factor receptor mutations and mutation patterns in the Turkish population. Methods: We retrospectively reviewed molecular pathology reports of 959 cases with lung cancer analysed for epidermal growth factor receptor mutations. We analysed all four epidermal growth factor receptor exon mutations using a real-time polymerase chain reaction platform. Results: In this study, the epidermal growth factor receptor mutation rate in the Turkish population was 16.7% (160 of 959). The epidermal growth factor receptor mutation frequency was significantly higher in women (37.1%, n=96) than in men (9.1%, n=64) (p |
| Databáze: | Directory of Open Access Journals |
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