Utilization of RESOLV with polymer to produce prazosin hydrochloride nanoparticles and optimization of the process parameters

Autor:	Eslam Ansari, Bizhan Honarvar, Seyed Ali Sajadian, Zahra Arab Aboosadi, Mehdi Azizi
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Prazosin hydrochloride RESOLV Optimization Taguchi Polyvinyl pyrrolidone Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-69128-6
Popis:	Abstract In this study, rapid expansion of a supercritical solution into a Liquid Solvent (RESOLV) was used for the first time to produce pharmaceutical nanoparticles of Prazosin hydrochloride (PRH). The Taguchi method (robust design) was utilized to design the experiments and ensure obtaining the optimal process conditions. The pressure (15–25 MPa), temperature (308–328 K) and nozzle diameter (300–700 μm) effects on the morphology and size distribution of the resulting particles were also examined. The size of the particles decreased from about 40 μm to the range of (252–418 nm). FTIR, DLS, FESEM, XRD, DSC were used to characterize the primary and processed PRH particles. According to DSC investigations, RESOLV-produced PRH showed lower crystallinity than original PRH.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b1e97d8b56de4c618471200082acb5a3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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