Increased insulin resistance with reduced beta cell function in recovered COVID-19 Ghanaians

Autor: Richard Kujo Adatsi, Ansumana Sandy Bockarie, Leonard Derkyi-Kwarteng, Faustina Pappoe, Paul Nsiah, Kwabena Dankwa, Samuel Acquah
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Endocrine and Metabolic Science, Vol 13, Iss , Pp 100150- (2023)
Druh dokumentu: article
ISSN: 2666-3961
DOI: 10.1016/j.endmts.2023.100150
Popis: Aim: This study compares levels of insulin resistance and beta-cell function and their relationship with liver enzymes in recovered COVID-19 participants and their uninfected counterparts in a cross-sectional study design in the Tamale metropolis of Ghana. Methods: Biochemical indices for liver function, lipid metabolism, inflammation and oxidative stress were assessed under fasting state in 110 recovered COVID-19 and 116 uninfected participants. The homeostatic model assessment of insulin resistance (HOMA-IR) and the triglyceride-glucose index (TyG) were employed for the assessment of insulin resistance. Results: Recovered COVID-19 participants presented lower (P 0.05) between the study groups. Prevalence of insulin resistance ranged from 61 % (71/116) to 81 % (89/110) for the uninfected and recovered COVID-19 participants respectively. Selected liver enzymes associated with HOMA-IR and TyG. Conclusion: The risk of developing type 2 diabetes mellitus appears higher in recovered COVID-19 participants than their uninfected counterparts despite the high prevalence of insulin resistance in both groups.
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