TNF controls a speed-accuracy tradeoff in the cell death decision to restrict viral spread

Autor: Jennifer Oyler-Yaniv, Alon Oyler-Yaniv, Evan Maltz, Roy Wollman
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-23195-9
Popis: Controlled cell death can be an efficient anti-viral strategy, but also leads to tissue damage and needs to be balanced. Oyler-Yaniv et al. combine mathematical modelling and microscopy to show that exposure to TNF in response to viral infection causes cells to tune their speed-vs-accuracy trade-off in cell death decision to limit HSV-1 spread.
Databáze: Directory of Open Access Journals