Sex disparities in vitamin D status and the impact on systemic inflammation and survival in rectal cancer

Autor:	Hanna Abrahamsson, Sebastian Meltzer, Vidar Nyløkken Hagen, Christin Johansen, Paula A. Bousquet, Kathrine Røe Redalen, Anne Hansen Ree
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Rectal cancer Vitamin D Sex Inflammation Survival Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	BMC Cancer, Vol 21, Iss 1, Pp 1-9 (2021)
Druh dokumentu:	article
ISSN:	1471-2407
DOI:	10.1186/s12885-021-08260-2
Popis:	Abstract Background We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating levels of 25-hydroxyvitamin D [25(OH) D] were low. Here we investigated whether the association between the vitamin D status and prognosis pertains to the general, unselected population of rectal cancer patients. Methods Serum 25(OH) D at the time of diagnosis was assessed in 129 patients, enrolled 2013–2017 and representing the entire range of rectal cancer stages, and analyzed with respect to season, sex, systemic inflammation, and survival. Results In the population-based cohort residing at latitude 60°N, 25(OH) D varied according to season in men only, who were overrepresented among the vitamin D-deficient (
Databáze:	Directory of Open Access Journals
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