| Autor: |
Danni Cheng, Ke Qiu, Yufang Rao, Minzi Mao, Li Li, Yan Wang, Yao Song, Junren Chen, Xiaowei Yi, Xiuli Shao, Shao Hui Huang, Yi Zhang, Xuemei Chen, Sisi Wu, Shuaishuai Yu, Jun Liu, Haiyang Wang, Xingchen Peng, Daibo Li, Lin Yang, Li Chen, Zhiye Ying, Yongbo Zheng, Meijun Zheng, Binwu Ying, Xiaoxi Zeng, Wei Zhang, Wei Xu, Geoffrey Liu, Fei Chen, Haopeng Yu, Yu Zhao, Jianjun Ren |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
eLife, Vol 12 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2050-084X |
| DOI: |
10.7554/eLife.82705 |
| Popis: |
The survival prognosis of human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) is largely different, and little is known about the anti-tumor mechanism of tumor-infiltrated exhausted CD8+ T cells (Tex) in HNSCC. We performed cell-level multi-omics sequencing on human HNSCC samples to decipher the multi-dimensional characteristics of Tex cells. A proliferative exhausted CD8+ T cell cluster (P-Tex) which was beneficial to survival outcomes of patients with HPV-positive HNSCC was identified. Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. P-Tex cells could aggregate in the antigen-presenting cell niches and activate certain signaling pathways. Together, our findings suggest a promising role for P-Tex cells in the prognosis of patients with HPV-positive HNSCC by providing modest but persistent anti-tumor effects. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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