Phylogenetic and Ecologic Perspectives of a Monkeypox Outbreak, Southern Sudan, 2005

Autor: Yoshinori Nakazawa, Ginny L. Emerson, Darin S. Carroll, Hui Zhao, Yu Li, Mary G. Reynolds, Kevin L. Karem, Victoria A. Olson, R. Ryan Lash, Whitni B. Davidson, Scott K. Smith, Rebecca S. Levine, Russell L. Regnery, Scott A. Sammons, Michael A. Frace, Elmangory M. Mutasim, Mubarak E. M. Karsani, Mohammed O. Muntasir, Alimagboul A. Babiker, Langova Opoka, Vipul Chowdhary, Inger K. Damon
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 19, Iss 2, Pp 237-245 (2013)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid1902.121220
Popis: Identification of human monkeypox cases during 2005 in southern Sudan (now South Sudan) raised several questions about the natural history of monkeypox virus (MPXV) in Africa. The outbreak area, characterized by seasonally dry riverine grasslands, is not identified as environmentally suitable for MPXV transmission. We examined possible origins of this outbreak by performing phylogenetic analysis of genome sequences of MPXV isolates from the outbreak in Sudan and from differing localities. We also compared the environmental suitability of study localities for monkeypox transmission. Phylogenetically, the viruses isolated from Sudan outbreak specimens belong to a clade identified in the Congo Basin. This finding, added to the political instability of the area during the time of the outbreak, supports the hypothesis of importation by infected animals or humans entering Sudan from the Congo Basin, and person-to-person transmission of virus, rather than transmission of indigenous virus from infected animals to humans.
Databáze: Directory of Open Access Journals
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