Can Mean Platelet Volume and Platelet Distribution Width be used as Predictive Markers for Impending Diabetic Vascular Complications?
| Autor: | Lavanya Rajagopal, Sundaram Arunachalam, Saleh Mohammed Abdullah, Vinothkumar Ganesan, Kumerasan Kathamuthu, Balaji Ramraj |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 12, Iss 2, Pp EC01-EC05 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2018/32574.11150 |
| Popis: | Introduction: Diabetes Mellitus (DM) has been considered as a prothrombotic state which has impact on a wide series of pathways regulating platelet function, the cornerstone is represented by increased platelet reactivity. Many hypothesis have attempted to explain the pathophysiological mechanism by which these hyperreactive platelets contribute to diabetic vascular complications. However, a comprehensive analysis of the relationship between platelet indices and diabetic status is still lacking. Aim: To analyse platelet indices with glycaemic status in type-2 DM patients and to establish the correlation between Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Fasting Blood Sugar (FBS) and Glycated haemoglobin (HbA1c) values. Materials and Methods: A cross-sectional study was carried out in SRM Medical College Hospital and Research Centre, Chennai, Tamil Nadu, India. Totally 450 subjects (150 controlled and 150 uncontrolled diabetics, 150 non-diabetics) were included and investigated for HbA1c, FBS and platelet indices. Statistical analysis using IBM SPSS software version 20.0. Statistical significant p-value was considered at |
| Databáze: | Directory of Open Access Journals |
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