Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors

Autor: R. A. Pearson, A. Gonzalez-Cordero, E. L. West, J. R. Ribeiro, N. Aghaizu, D. Goh, R. D. Sampson, A. Georgiadis, P. V. Waldron, Y. Duran, A. Naeem, M. Kloc, E. Cristante, K. Kruczek, K. Warre-Cornish, J. C. Sowden, A. J. Smith, R. R. Ali
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms13029
Popis: Transplantation of healthy photoreceptor cells has been shown to rescue blindness. Here, the authors show that rather than donor cells integrating into the host retina, the predominant mechanism underlying this rescue involves exchange of cytoplasmic material between donor and host cells in vivo.
Databáze: Directory of Open Access Journals