Network analysis methods for studying microbial communities: A mini review

Autor: Monica Steffi Matchado, Michael Lauber, Sandra Reitmeier, Tim Kacprowski, Jan Baumbach, Dirk Haller, Markus List
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2687-2698 (2021)
Druh dokumentu: article
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2021.05.001
Popis: Microorganisms including bacteria, fungi, viruses, protists and archaea live as communities in complex and contiguous environments. They engage in numerous inter- and intra- kingdom interactions which can be inferred from microbiome profiling data. In particular, network-based approaches have proven helpful in deciphering complex microbial interaction patterns. Here we give an overview of state-of-the-art methods to infer intra-kingdom interactions ranging from simple correlation- to complex conditional dependence-based methods. We highlight common biases encountered in microbial profiles and discuss mitigation strategies employed by different tools and their trade-off with increased computational complexity. Finally, we discuss current limitations that motivate further method development to infer inter-kingdom interactions and to robustly and comprehensively characterize microbial environments in the future.
Databáze: Directory of Open Access Journals