| Autor: |
Milena Jovanović, Katarina Virijević, Dejan Arsenijević, Katarina Pecić, Dragana Šeklić |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Engineering Proceedings, Vol 56, Iss 1, p 186 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2673-4591 |
| DOI: |
10.3390/ASEC2023-15961 |
| Popis: |
Royal jelly (RJ), as an exclusive bee product, showed beneficial effects on various human pathological conditions, including cancer. Therefore, we examined the effects of RJ on the suppression of invasiveness of SW-480 cells and protein expression of Vimentin and Snail, markers of cancer cell invasive properties. This natural treatment suppressed the aggressive behavior of tested cells by inhibiting the expression of transcription factor Snail, and consequently the expression of cytoskeletal protein Vimentin with a key role in supporting invasive potential. In conclusion, our report indicates the possible molecular mechanism of anti-invasive activity of RJ on the colorectal carcinoma cell line via the inhibition of Vimentin and Snail protein expression. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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