| Autor: |
Jiayu Huang, Yeqian Zhao, Chuanhe Jiang, Dongsheng Han, Zengkai Pan, Zilu Zhang, Luxiang Wang, Wei Chen, Su Li, Yanmin Zhao, Xiaoxia Hu |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2235-2988 |
| DOI: |
10.3389/fcimb.2023.1251509 |
| Popis: |
IntroductionImmunosuppression predisposes allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients to infection. Prompt and accurate identification of pathogens is crucial to optimize treatment strategies. This multi-center retrospective study aimed to assess the ability of metagenomic next-generation sequencing (mNGS) to detect causative pathogens in febrile allo-HSCT recipients and examined its concordance with conventional microbiological tests (CMT).MethodsWe performed mNGS and CMT on samples obtained from 153 patients with suspected infection during allo-HSCT. Patients were grouped based on their neutropenic status at the time of sampling.ResultsThe mNGS test was more sensitive than CMT (81.1% vs. 53.6%, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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