Rotavirus A infection in children under five years old with a double health problem: undernutrition and diarrhoea – a cross-sectional study in four provinces of Mozambique

Autor: Assucênio Chissaque, Marta Cassocera, Carolina Gasparinho, Jéronimo Souzinho Langa, Adilson Fernando Loforte Bauhofer, Jorfélia José Chilaúle, Eva Dora João, Benilde António Munlela, Júlia Assiat Monteiro Sambo, Simone Salvador Boene, Marlene Bernardo Djedje, Elda Muianga Anapakala, Esperança Lourenço Guimarães, Diocreciano Matias Bero, Lena Vânia Manhique-Coutinho, Idalécia Cossa-Moiane, Timothy A. Kellogg, Luzia Augusta Pires Gonçalves, Nilsa de Deus
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 1471-2334
DOI: 10.1186/s12879-020-05718-9
Popis: Abstract Background Mozambique has a high burden of group A rotavirus (RVA) infection and chronic undernutrition. This study aimed to determine the frequency and potential risk factors for RVA infection in undernourished children under 5 years old with diarrhoea in Mozambique. Methods The analysis was conducted using data from March 2015 to December 2017, regarding children under 5 years old with at least one type of undernutrition. Anthropometric measures were used to calculate indices of weight-for-age, weight-for-height and height-for-age through the Z-Scores. RVA results were extracted from the National Diarrhoea Surveillance database. Descriptive statistics, chi-square test was used for qualitative variables and organized in contingency tables and 95% Confidence Intervals (CI) were considered for the calculation of RVA infection proportion and in the multiple logistic regression models to estimate the adjusted odds ratios (AOR). Results Of the 842 undernourished children included in the analysis, 27.2% (95% CI: 24.3–30.3%) were positive for RVA. The rate of RVA infection was 42.7% (95% CI: 38.0–47.5%) in the pre-vaccine period, with great reduction to 12.2% (95% CI: 9.4–15.6%) in the post-vaccine period. Most of the RVA undernourished children had severe wasting (33.3%) and severe stunting (32.0%). The risk of infection was significantly high in children from 0 to 11 months (p-value
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