Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism

Autor: Alireza Ostadrahimi, Taher Manzari, Sahar Gohari-Lasaki, Helda Tutunchi, Majid Mobasseri, Vahideh Sadra, Farzad Najafipour
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Research Notes, Vol 16, Iss 1, Pp 1-5 (2023)
Druh dokumentu: article
ISSN: 1756-0500
DOI: 10.1186/s13104-023-06516-7
Popis: Abstract Objectives This study investigated the effects of levothyroxine replacement therapy on insulin resistance, lipid profile, and thyroid function in patients with untreated primary hypothyroidism. 105 patients with hypothyroidism with indication for levothyroxine replacement were enrolled in the present study. Insulin, fasting blood glucose and lipid profile were assessed at the beginning of diagnosis and three months after levothyroxine replacement. Insulin resistance was calculated by hemostasis model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). Results Our data revealed a significant reduction in body mass index (27.18 ± 4.27 versus 26.81 ± 4.18 kg/m2, p = 0.028), cholesterol (199.79 ± 37.61 versus 178.10 ± 32.25 mg/dl, p
Databáze: Directory of Open Access Journals
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