Electrophysiological Changes of Sensory Nerves in Patients with Type-2 Diabetes Mellitus of Different Duration

Autor: Sharmeen Sultana, Noorzahan Begum, Liaquat Ali, Md Mosharrof Hossain, Nirmelendu Bikash Bhowmik, Shahana Parveen, Zinia Perveen
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Bangabandhu Sheikh Mujib Medical University Journal, Vol 3, Iss 1 (2010)
Druh dokumentu: article
ISSN: 2074-2908
2224-7750
DOI: 10.3329/bsmmuj.v3i1.5507
Popis: Background: Peripheral neuropathy is a common complication of diabetes mellitus. Among the diabetic neuropathies symmetrical sensory polyneuropathy is the most common one. Abnormalities of sensory nerve conduction are features of diabetic nerve damage. Significant association has been found between electrophysiological parameters of sensory nerves and duration of metabolic derangement in patients with diabetic neuropathy. Objectives: The present study was designed to characterize nerve conduction abnormalities of sensory nerves in subjects with type 2 diabetes mellitus of different duration and also to assess whether duration of diabetes has any influence on the sensory nerve function. Methods: Forty-four type 2 diabetic subjects were included in two groups:- Group B1 consisted of 23 diabetic subjects having duration of diabetes for 5-10 years (shorter duration) and Group B2 consisted of 21 diabetic subjects having duration of diabetes for 10-15 years (longer duration). Twenty-five age and BMI matched healthy subjects without family history of diabetes were included as Group A (control) subjects. Sensory nerve conduction velocities, action potential amplitudes and latencies of ulnar and sural nerves were measured by a standard NCV-EMG equipment. Result: No significant changes in sensory nerve conduction parameters were observed in the group of diabetic subjects having shorter duration of diabetes. In the diabetic group with relatively longer duration of diabetes some of the sensory nerve conduction parameters were affected. Among them S SNAP and S NCV were significantly (P
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