Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies

Autor: Chachrit Khunsriraksakul, Daniel McGuire, Renan Sauteraud, Fang Chen, Lina Yang, Lida Wang, Jordan Hughey, Scott Eckert, J. Dylan Weissenkampen, Ganesh Shenoy, Olivia Marx, Laura Carrel, Bibo Jiang, Dajiang J. Liu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-30956-7
Popis: Transcriptome-wide association studies can be used to test the effects of predicted gene expression in a cohort of individuals based on genetic data. Here, the authors developed a transcriptome-wide association method that integrates 3D genomic and epigenomic data with expression quantitative trait loci to improve gene expression predictions.
Databáze: Directory of Open Access Journals