Effect of the combination of mexidol and diclofenac sodium on exudative inflammation in rats after ten-day preventive oral administration
| Autor: | E. A. Ivanova, A. G. Vasilchuk, A. I. Matyushkin, T. A. Voronina |
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| Jazyk: | ruština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 14-19 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2587-7836 2686-8830 |
| DOI: | 10.37489/2587-7836-2022-1-14-19 |
| Popis: | In rats with carrageenan-induced paw edema, diclofenac sodium significantly reduces exudation after ten-day preventive oral administration at a dose of 10 mg/kg but not 5 mg/kg. Mexidol at a dose of 100 mg/kg in combination with diclofenac sodium at a dose of 5 mg/kg (preventively orally, during 10 days, once a day) reduces paw edema during the first two out of four hours of its recording compared with the control group. However, ten-day preventive oral administration of mexidol at a dose of 100 mg/kg (once a day) increases the severity of carrageenan-induced paw edema in rats at four hours after the injection of the phlogogen. |
| Databáze: | Directory of Open Access Journals |
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