| Autor: |
Chao Zhang, Jun Li, Rui Zhang, Bo Zhang, Li Tong, Peng Zhang, Jie Fan, Yue Ma, Chong Zhang, Si-Yu Wang, Xiang-Yu Wang, Jie-Liang Zuo, Xue-Fu Wang, Xiao-Wen Feng, Yi-Tong Li, Chen-He Yi, Xiao-Chen Ma, Zhen-Mei Chen, Jia-Hao Han, Bao-Rui Tao, Tian-Qi Wang, Wang Gu, Xiao-Fei Zheng, Wen-Kang Yuan, Zi-Jie Kan, Xiang-Yang Hu, Jin-Hong Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2051-1426 |
| DOI: |
10.1136/jitc-2022-006425 |
| Popis: |
Background Tertiary lymphoid structures (TLSs) have been proposed to assess the prognosis of patients with cancer. Here, we investigated the prognostic value and relevant mechanisms of TLSs in colorectal cancer liver metastases (CRCLM).Methods 603 patients with CRCLM treated by surgical resection from three cancer centers were included. The TLSs were categorized according to their anatomic subregions and quantified, and a TLS scoring system was established for intratumor region (T score) and peritumor region (P score). Differences in relapse-free survival (RFS) and overall survival (OS) between groups were determined. Multiplex immunohistochemical staining (mIHC) was used to determine the cellular composition of TLSs in 40 CRCLM patients.Results T score positively correlated with superior prognosis, while P score negatively associated with poor survival (all p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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