Assessing Safety of Anticoagulation for Atrial Fibrillation in Patients with Cirrhosis: A Real-World Outcomes Study
| Autor: | Justin J. Song MD, Nicholas J. Jackson PhD, MPH, Helen Shang MD, Henry M. Honda MD, Kristin Boulier MD |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Journal of Cardiovascular Pharmacology and Therapeutics, Vol 29 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1940-4034 10742484 |
| DOI: | 10.1177/10742484241256271 |
| Popis: | Aims In patients with atrial fibrillation (AF) and stroke risk factors, randomized trials have demonstrated that anticoagulation decreases the risk of ischemic stroke. However, all trials to date have excluded patients with significant liver disease, leaving guidelines to extrapolate recommendations. We aim to evaluate the impact of anticoagulation on safety events in patients with AF and cirrhosis. Methods and Results In this retrospective cohort study, we obtained de-identified health record data to extract anticoagulation strategy, comorbidities, prescriptions, lab values, and procedures for a cohort of patients with cirrhosis who develop AF. After selecting a propensity matched population to match patients with various anticoagulation strategies, we tracked data on outcomes for death, transfusion requirements, hospital and ICU admissions. After propensity score weighting and multivariable adjustment, anticoagulation strategy was associated with increased hospital admission count (OR = 1.74 per admission, P |
| Databáze: | Directory of Open Access Journals |
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