High prevalence of vertebral fractures associated with preoperative cortisol levels in patients with recent diagnosis of Cushing disease
| Autor: | Heng Sun, Chunli Wu, Biao Hu, Genqing Xie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Annals of Medicine, Vol 55, Iss 2 (2023) |
| Druh dokumentu: | article |
| ISSN: | 07853890 1365-2060 0785-3890 |
| DOI: | 10.1080/07853890.2023.2282183 |
| Popis: | AbstractBackground/objective Morphometric vertebral fractures (VFs) and osteopathy are prevalent and clinically significant complications of Cushing disease (CD). However whether they represent an early occurrence in the natural progression of the disease is an ongoing debate. This study aimed to assess the prevalence and determinants of VFs in patients newly diagnosed with CD.Patients and methods This cross-sectional case–control study recruited 75 newly diagnosed CD patients and compared them with a control group of individuals without pituitary disorders or secondary forms of osteoporosis. Demographic, clinical and biochemical data were collected. The VFs were assessed using preoperative lateral chest radiography.Results We found a significantly higher prevalence of VFs in the CD group than in the control group (58.7% vs. 14.5%; P |
| Databáze: | Directory of Open Access Journals |
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