| Autor: |
Avi Kaye, Matthew Rusling, Amey Dhopeshwarkar, Parhesh Kumar, Lauren Wagment-Points, Kenneth Mackie, Li-Lian Yuan |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Frontiers in Microbiomes, Vol 3 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2813-4338 |
| DOI: |
10.3389/frmbi.2024.1412468 |
| Popis: |
IntroductionObesity and high-fat diets induce consistent alterations in gut microbiota composition. Observations from epidemiological reviews and experiments also illustrate weight regulation effects of delta9-tetrahydrocannabinol (THC) with microbiome shifts. Therefore, we investigated the weight-loss potential of THC in obese mice models and to elucidate the contribution of specific gut microbiome changes in THC-induced weight loss.MethodsHigh-fat diet induced obese mice were treated with oral THC supplementation for two weeks and compared with controls. In addition to measuring weight, fecal samples were obtained at various timepoints, sequenced for bacterial 16s rRNA content and analyzed using QIIME2. Alpha and beta diversity were computed followed by linear mixed effects (LME) modeling of bacterial relative abundance relationship to THC treatment and weight change.ResultsIn both male and female mice, the THC group had significantly greater average weight loss than controls (−17.8% vs. −0.22%, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
