| Autor: |
Jed Wingrove, Janine Makaronidis, Ferran Prados, Baris Kanber, Marios C. Yiannakas, Cormac Magee, Gloria Castellazzi, Louis Grandjean, Xavier Golay, Carmen Tur, Olga Ciccarelli, Egidio D'Angelo, Claudia A.M. Gandini Wheeler-Kingshott, Rachel L. Batterham |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
EClinicalMedicine, Vol 58, Iss , Pp 101883- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2589-5370 |
| DOI: |
10.1016/j.eclinm.2023.101883 |
| Popis: |
Summary: Background: Olfactory impairments and anosmia from COVID-19 infection typically resolve within 2–4 weeks, although in some cases, symptoms persist longer. COVID-19-related anosmia is associated with olfactory bulb atrophy, however, the impact on cortical structures is relatively unknown, particularly in those with long-term symptoms. Methods: In this exploratory, observational study, we studied individuals who experienced COVID-19-related anosmia, with or without recovered sense of smell, and compared against individuals with no prior COVID-19 infection (confirmed by antibody testing, all vaccine naïve). MRI Imaging was carried out between the 15th July and 17th November 2020 at the Queen Square House Clinical Scanning Facility, UCL, United Kingdom. Using functional magnetic resonance imaging (fMRI) and structural imaging, we assessed differences in functional connectivity (FC) between olfactory regions, whole brain grey matter (GM) cerebral blood flow (CBF) and GM density. Findings: Individuals with anosmia showed increased FC between the left orbitofrontal cortex (OFC), visual association cortex and cerebellum and FC reductions between the right OFC and dorsal anterior cingulate cortex compared to those with no prior COVID-19 infection (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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