| Autor: |
Wiwied Ekasari, Retno Widyowati, Tutik S. Wahyuni, Suciati, Rice D. Oktarina, Chrismawan Ardianto, Elsa S. Prameswari, Windri A. A. Suri, Alfaniady I. Kurnia, Rahma K. Wirabuana, Vita M. A. Angembani, Ram K. Sahu |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacy & Pharmacognosy Research, Vol 11, Iss 6, Pp 1072-1078 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0719-4250 |
| DOI: |
10.56499/jppres23.1579_11.6.1072 |
| Popis: |
Context: Senna spectabilis (DC.) H.S.Irwin & Barnebywhich belongs to Fabaceae family is widely used traditionally in the treatment of various diseases and disorders such as constipation, insomnia, anxiety, epilepsy, malaria and skin diseases. Aims: To investigate the central nervous system (CNS) depressant effect of 70% ethanol extract of S. spectabilis leaves (70SSEE) using different neuropharmacological models in mice. Methods: The CNS depressant effect of 70SSEE was investigated by the classical models of depression as elevated plus maze (EPM), hole cross (HC), and thiopental sodium (TS)-induced sleeping time tests in mice. The EPM test was used to assess the anxiolytic activity of 70SSEE at doses of 10, 50, and 100 mg/kg, while HC and TS-induced sleeping time tests at doses of 100, 250, and 500 mg/kg were used to assess the locomotor and sedative activity in mice. Results: In EPM test, 70SSEE at doses of 50 and 100 mg/kg significantly (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
