Specific CpG sites methylation is associated with hematotoxicity in low-dose benzene-exposed workers

Autor: Feier Wang, Lizhu Ye, Xinhang Jiang, Rui Zhang, Shen Chen, Liping Chen, Hongyao Yu, Xiaowen Zeng, Daochuan Li, Xiumei Xing, Yongmei Xiao, Wen Chen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Environment International, Vol 186, Iss , Pp 108645- (2024)
Druh dokumentu: article
ISSN: 0160-4120
DOI: 10.1016/j.envint.2024.108645
Popis: Benzene is a broadly used industrial chemicals which causes various hematologic abnormalities in human. Altered DNA methylation has been proposed as epigenetic biomarkers in health risk evaluation of benzene exposure, yet the role of methylation at specific CpG sites in predicting hematological effects remains unclear. In this study, we recruited 120 low-level benzene-exposed and 101 control male workers from a petrochemical factory in Maoming City, Guangdong Province, China. Urinary S-phenylmercapturic acid (SPMA) in benzene-exposed workers was 3.40-fold higher than that in control workers (P
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